SubtiBank SubtiBank
proH [2017-08-22 16:04:13]
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proH [2017-08-22 16:04:13]

pyrroline-5-carboxylate reductase
Locus
BSU18480
Isoelectric point
7.75
Molecular weight
31.88 kDa
Protein length
297 aa Sequence Blast
Gene length
891 bp Sequence Blast
Function
osmoadaptive de novo production of proline
Product
pyrroline-5-carboxylate reductase
Essential
no
E.C.
1.5.1.2
Synonyms
yoxE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of proline
  • Lifestyles → Coping with stress → Coping with hyper-osmotic stress

    • Gene

    Coordinates
    2,016,845 → 2,017,738

    The protein

    Catalyzed reaction/ biological activity

  • 1-pyrroline-5-carboxylate + NADPH + H+ --> L-proline + NADP+ PubMed

    • Protein family

  • pyrroline-5-carboxylate reductase family PubMed

    • Paralogous protein(s)

  • ProI

    • Cofactors

  • NADPH PubMed

    • Effectors of protein activity

  • feedback-inhibited by proline PubMed

    • Structure

  • 5BSE (from Medicago trunculata, 36% identity)

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    proH-proJ
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulation

  • expressed under conditions of osmotic stress PubMed
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    Biological materials

    Mutant

  • MGNA-B083 (proH::erm), available at the NBRP B. subtilis, Japan

    • References

    Reviews

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    Original publications

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